The Ras superfamily is comprised of at least four large families of regulatory guanosine triphosphate–binding proteins, including the Arfs. The Arf family includes three different groups of proteins: the Arfs, Arf-like (Arls), and SARs. Several Arf family members have been very highly conserved throughout eukaryotic evolution and have orthologues in evolutionally diverse species. The different means by which Arf family members have been identified have resulted in an inconsistent and confusing array of names. This confusion is further compounded by differences in nomenclature between different species. We propose a more consistent nomenclature for the human members of the Arf family that may also serve as a guide for nomenclature in other species.
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27 February 2006
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February 27 2006
Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins
Richard A. Kahn,
Richard A. Kahn
1Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322
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Jacqueline Cherfils,
Jacqueline Cherfils
2Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France
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Marek Elias,
Marek Elias
3Department of Plant Physiology, Faculty of Science, Charles University, 128 44 Prague 2, Czech Republic
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Ruth C. Lovering,
Ruth C. Lovering
4Human Genome Organisation Gene Nomenclature Committee, Galton Laboratory, Department of Biology, University College London, London NW1 2HE, United Kingdom
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Sean Munro,
Sean Munro
5Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
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Annette Schurmann
Annette Schurmann
6Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbrücke, D-14558 Nuthetal, Germany
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Richard A. Kahn
1Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322
Jacqueline Cherfils
2Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France
Marek Elias
3Department of Plant Physiology, Faculty of Science, Charles University, 128 44 Prague 2, Czech Republic
Ruth C. Lovering
4Human Genome Organisation Gene Nomenclature Committee, Galton Laboratory, Department of Biology, University College London, London NW1 2HE, United Kingdom
Sean Munro
5Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
Annette Schurmann
6Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbrücke, D-14558 Nuthetal, Germany
Correspondence to Richard A. Kahn: [email protected]
Abbreviations used in this paper: GDP, guanosine diphosphate; TRIM, tripartite motif.
Received:
December 09 2005
Accepted:
January 24 2006
Online ISSN: 1540-8140
Print ISSN: 0021-9525
The Rockefeller University Press
2006
J Cell Biol (2006) 172 (5): 645–650.
Article history
Received:
December 09 2005
Accepted:
January 24 2006
Citation
Richard A. Kahn, Jacqueline Cherfils, Marek Elias, Ruth C. Lovering, Sean Munro, Annette Schurmann; Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins . J Cell Biol 27 February 2006; 172 (5): 645–650. doi: https://doi.org/10.1083/jcb.200512057
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