Signal-mediated export of proteins from the malaria parasite to the host erythrocyte

Marti , Matthias; Baum , Jake; Rug , Melanie; Tilley , Leann; Cowman , Alan F.

doi:10.1083/jcb.200508051

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Review| November 21 2005

Signal-mediated export of proteins from the malaria parasite to the host erythrocyte

Matthias Marti,

Matthias Marti

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

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Jake Baum,

Jake Baum

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

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Melanie Rug,

Melanie Rug

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

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Leann Tilley,

Leann Tilley

2Department of Biochemistry, La Trobe University, Melbourne, Victoria 3000, Australia

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Alan F. Cowman

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

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Author and Article Information

Matthias Marti

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

Jake Baum

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

Melanie Rug

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

Leann Tilley

2Department of Biochemistry, La Trobe University, Melbourne, Victoria 3000, Australia

Alan F. Cowman

1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

Correspondence to Alan F. Cowman: [email protected]

Abbreviations used in this paper: DBL, duffy binding-like; iRBC, infected RBC; KAHRP, knob-associated histidine-rich protein; PEXEL, Plasmodium export element; PfEMP, P. falciparum erythrocyte membrane protein; PHIST, Plasmodium helical interspersed subtelomeric family; PVM, parasitophorous vacuole membrane; RESA, ring-infected erythrocyte surface antigen.

Received: August 05 2005

Accepted: October 17 2005

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2005

J Cell Biol (2005) 171 (4): 587–592.

https://doi.org/10.1083/jcb.200508051

Intracellular parasites from the genus Plasmodium reside and multiply in a variety of cells during their development. After invasion of human erythrocytes, asexual stages from the most virulent malaria parasite, P. falciparum, drastically change their host cell and export remodelling and virulence proteins. Recent data demonstrate that a specific NH₂-terminal signal conserved across the genus Plasmodium plays a central role in this export process.

The Rockefeller University Press

2005

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