By the mid-1970s, the idea of a transmembrane molecule linking the cytoskeleton to the extracellular matrix (ECM) had some supporting evidence. Adhesion molecules were hot in areas ranging from developmental biology to tumor biology, and the mounting suggestive evidence that a “fibronectin receptor” existed made it a “Holy Grail” for the next decade, recalls Richard Hynes, discoverer of fibronectin, in a memoir (Hynes, 2004).
An anti-integrin antibody (bottom) makes cells float.
HORWITZ
Not only did...
The Rockefeller University Press
2005
The Rockefeller University Press
2005
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