Capacitative calcium entry sensing the calcium stores

Putney , James W.

doi:10.1083/jcb.200503161

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Spotlight| May 02 2005

Capacitative calcium entry : sensing the calcium stores

James W. Putney, Jr.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health Department of Health and Human Services, Research Triangle Park, NC 27709

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Author and Article Information

James W. Putney, Jr.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health Department of Health and Human Services, Research Triangle Park, NC 27709

Correspondence to James W. Putney, Jr: [email protected]

Abbreviations used in this paper: CIF, calcium influx factor; IP₃, inositol 1,4,5-trisphosphate; SAM, sterile α motif; STIM, stromal interaction molecule.

Received: March 29 2005

Accepted: April 04 2005

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2005

J Cell Biol (2005) 169 (3): 381–382.

https://doi.org/10.1083/jcb.200503161

A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.

The Rockefeller University Press

2005

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