Rolling lymphocytes do not gradually decelerate before stopping.
ALON/MACMILLAN
Lymphocytes and other white blood cells roll along vessel walls scanning for immobilized chemokine signals that tell them where to stop on the endothelium. They only stop once their integrins, which are otherwise kept bent and inactive, are properly activated. As arrest requires dramatic adhesion changes, most scientists assumed that rolling allowed signals to accumulate and globally activate integrins, thus decelerating and eventually stopping the rolling cell. In some settings, such as neutrophils rolling on E-selectin, deceleration lasts several minutes. But the new findings show a much more abrupt stop of lymphocytes on the endothelium.
Rolling was not even necessary for neutrophils to stop. Endothelium-bound chemokines needed...
