ICs move randomly within the central nuclear pore.
Musser/NAS
The group imaged single import complexes (ICs)—importin(s) and cargo—interacting with NPCs. Trajectories of the ICs within the pore indicate rapid, random movement forward and backward.
One transport model proposes an affinity gradient across the pore between ICs and pore components, but the back and forth movements do not support this model. Rather, the data suggest that molecules move randomly within the pore and exit either side. “If the IC enters the pore and reexits the same side,” says Musser, “no net energy went in, so you've lost nothing. But if the IC gets out the other side,...
The Rockefeller University Press
2004
The Rockefeller University Press
2004
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