Calcium signals from outside

Calcium just got a promotion. Findings by Caroppo et al. (page 111) reveal that in addition to its many roles inside the cell, Ca²⁺ has a distinct extracellular purpose: it acts via a Ca²⁺receptor (CaR) to regulate the function of gastric epithelial cells.

It has been known for some time that extracellular Ca²⁺ can be sensed by the CaR. The team noted that a Ca²⁺ gradient was generated outside gastric cells after cholinergic stimulation with carbachol, which mimics a signal received during digestion processes. Ca²⁺ levels increased on the apical side and decreased on the basolateral side, and prompted secretion of pepsinogen. Proteolytic cleavage of pepsinogen yields the digestive enzyme pepsin.

It is well known that carbachol boosts intracellular Ca²⁺ in...