MCSP (green) colocalizes with α4 integrin (red) as it amplifies the pathway activation seen during adhesion.
That costimulator is melanoma chondroitin sulfate proteoglycan (MCSP). MCSP is known to be an early cell surface marker during melanoma progression, and to stimulate tumorigenesis. When Yang et al. transfected MCSP into a melanoma cell lacking MCSP, the cells exhibited an increased propensity to undergo spreading, which was mediated in large part by focal adhesion kinase (FAK). Integrin-mediated activation of both FAK and ERK 1/2 were increased by MCSP expression, and activation of ERK 1/2 remained even when...
The Rockefeller University Press
2004
The Rockefeller University Press
2004
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