A caspase for stress

Stress in the endoplasmic reticulum (ER)—caused by anything from ischemia to expression of mutant proteins—triggers several responses. Cells slow translation, produce more chaperones, degrade more unfolded proteins, and as a last resort, induce apoptosis. Hitomi et al. (page 347) identify caspase-4 as a critical component of the pathway leading from ER stress to apoptosis, specifically after the expression of cytotoxic Aβ from Alzheimer's patients.

Caspase-12 has already been identified as mediating such a function in mice, but the caspase-12 gene in humans has frame-shifts and a premature stop codon. Hitomi et al. therefore screened cDNA libraries with mouse caspase-12 and came up with human caspase-4. Although some caspase-4 is found on mitochondria, the protein is also found on the ER, and its cleavage after ER stress or incubation with Aβ is not...