Yeast dies for a noble cause

The yeast Saccharomyces cerevisae is a popular model for studying apoptosis, raising an obvious mystery: why would a unicellular organism ever initiate programmed cell death? On page 501, Herker et al. elegantly demonstrate that under conditions simulating growth of yeast in the wild, suicide is an appropriate altruistic response.

After finding that cells in old yeast cultures die with the typical membranous and nuclear markers of apoptosis, the authors looked for a motive. Cells overexpressing Yap1p, which mediates the yeast stress response, enjoy prolonged survival in aging cultures, indicating that the death response is triggered by stress. Deleting the caspase YCA1 improves short-term survival, but YCA1 deletants fail to regrow when transferred from an old culture to fresh medium, and wild-type cells out-compete YCA1 deletants in cocultures. Yeast cells undergoing apoptosis release low molecular...