That commitment occurs during egg cell maturation. Frog egg cells mature from a paused G2-like state in response to a hormone stimulus. Even a transient stimulus pushes cells through maturation to meiosis II via a kinase/phosphatase cascade of ∼15 proteins, including p42 MAPK, cyclin B/Cdc2, and Cdc25. As phosphorylation is reversible but maturation is not, cells must somehow remember their hormone encounter. The authors now show that this memory lies in a positive feedback loop in the p42 pathway.
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The Rockefeller University Press
2003
The Rockefeller University Press
2003
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