Calcium mobilization from mitochondria in synaptic transmitter release

Rizzuto , Rosario

doi:10.1083/jcb.200309111

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Spotlight| November 10 2003

Calcium mobilization from mitochondria in synaptic transmitter release

Rosario Rizzuto

Department of Experimental and Diagnostic Medicine and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy

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Author and Article Information

Rosario Rizzuto

Department of Experimental and Diagnostic Medicine and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy

Address correspondence to Dr. Rosario Rizzuto Dept. of Experimental and Diagnostic Medicine, University of Ferrara, Via Borsari, 46 44100 Ferrara, Italy. Tel.: 39-0532-291-361. Fax: 39-0532-247-278. email: [email protected]

Abbreviations used in this paper: PKC, protein kinase C; PTP, permeability transition pore.

Received: September 17 2003

Accepted: October 10 2003

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2003

J Cell Biol (2003) 163 (3): 441–443.

https://doi.org/10.1083/jcb.200309111

Mitochondria can rapidly accumulate and release Ca²⁺ upon cell stimulation. A paper by Yang and coworkers in this issue reports an unusual form of synaptic potentiation, dependent on Ca²⁺ release from mitochondria through the Na⁺/Ca²⁺ exchanger and triggered by Na⁺ entry through voltage-gated channels (Yang et al., 2003).

The Rockefeller University Press

2003

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