Coping with the stress of morphogenesis

As a multicellular organism develops, its tissues are often subjected to powerful internal and external mechanical stresses. On page 757, Bosher et al. describe a set of critical reinforcements that allow C. elegans embryos to weather these forces rather than be torn apart. Besides illuminating a critical aspect of morphogenesis, the work establishes a new model for analyzing the coupling of tissues during development.

Using a genetic screen, the authors found that mutations in a locus called vab-10, which corresponds to spectraplakin, cause defects in the elongation of worm embryos. C. elegans vab-10 encodes two protein isoforms. Mutations that affect VAB-10A isoforms disrupt fibrous organelles, which are molecular and functional homologues of vertebrate hemidesmosomes. These mutations cause epidermal cells to detach from the cuticle and muscles during elongation. When VAB-10B isoforms are disrupted,...