Sweet solution sugars to the rescue

Freeze , Hudson H.

doi:10.1083/jcb.200207155

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Spotlight| August 19 2002

Sweet solution : sugars to the rescue

Hudson H. Freeze

The Burnham Institute, La Jolla Cancer Research Center, La Jolla, CA 92037

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Author and Article Information

Hudson H. Freeze

The Burnham Institute, La Jolla Cancer Research Center, La Jolla, CA 92037

Address correspondence to Hudson H. Freeze, The Burnham Institute, La Jolla Cancer Research Center, 10901 N. Torrey Pines Rd., La Jolla, CA 92037. Tel.: (858) 646-3142. Fax: (858) 713-6281. E-mail: [email protected]

*

Abbreviation used in this paper: CDG-IIc, congenital disorder of glycosylation II-c; dpc, days postcoitum; M/E, myeloid to erythroid.

Received: July 26 2002

Accepted: July 29 2002

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2002

J Cell Biol (2002) 158 (4): 615–616.

https://doi.org/10.1083/jcb.200207155

Sugar pills are usually placebos, but Smith et al. (2002, this issue) use one to rescue designer mice unable to make GDP-Fucose. Dietary fucose enters a salvage pathway and spares the mice. Sound simple? Not so. Unknown genetic factors determine life or death.

The Rockefeller University Press

2002

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