Normal Golgi structure (left) is lost in COG mutants (right).

Ungar et al. report on page 405 that three separately studied Golgi protein complexes are one and the same. The mammalian version of the complex has been named the conserved oligomeric Golgi (COG) complex.COG is octameric, and five of its eight subunits have homologues in the octameric Sec34/35 complex from budding yeast, which was recently isolated and characterized (Whyte, J.R.C., and S. Munro. 2001. Dev. Cell. 1:527–537). In addition, some of COG's subunits have previously been identified based on either an in vitro transport assay or studies of cell lines with Golgi glycosylation defects.

A detailed function for COG is not yet apparent, although mutant phenotypes in yeast and mammalian cells suggest that it participates either in forming Golgi structures or in controlling Golgi traffic. The yeast approach has subdivided the Sec34/35 complex into...

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