Simple centromere, complex kinetochore linking spindle microtubules and centromeric DNA in budding yeast

Cheeseman , Iain M.; Drubin , David G.; Barnes , Georjana

doi:10.1083/jcb.200201052

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Review| April 15 2002

Simple centromere, complex kinetochore : linking spindle microtubules and centromeric DNA in budding yeast

Iain M. Cheeseman,

Iain M. Cheeseman

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

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David G. Drubin,

David G. Drubin

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

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Georjana Barnes

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

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Author and Article Information

Iain M. Cheeseman

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

David G. Drubin

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

Georjana Barnes

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

Address correspondence to Georjana Barnes, Dept. of Molecular and Cell Biology, 401 Barker Hall #3202, University of California, Berkeley, CA 94720-3202. Tel.: (510) 642-5962. Fax: (510) 643-0062. E-mail: [email protected]

*

Abbreviation used in this paper: MAP, microtubule-associated protein.

Received: January 10 2002

Revision Received: February 26 2002

Accepted: February 28 2002

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2002

J Cell Biol (2002) 157 (2): 199–203.

https://doi.org/10.1083/jcb.200201052

Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation.

The Rockefeller University Press

2002

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Simple centromere, complex kinetochore : linking spindle microtubules and centromeric DNA in budding yeast

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