Repair long and prosper

Death can be a good thing when it comes to sunburn—the death of UVB-damaged cells reduces the chances of cancerous growths arising. But now, Thomas Schwarz (University of Münster, Münster, Germany) and colleagues have found a way that the body can reduce the evil effects of UVB without invoking death. A cytokine, IL-12, induces nucleotide excision repair (NER), and thus decreases DNA damage and apoptosis.Schwarz started out by looking for factors that enhanced apoptosis after UV treatment. Instead, he found the reverse effect with IL-12. A series of follow-up studies failed to demonstrate an underlying mechanism. “At the very end, more in desperation, we checked DNA damage,” he says. The finding of reduced DNA damage was a surprise, as cytokines have not previously been implicated in inducing NER. IL-12's protective effect seems to be dependent...