DNA decondensation with wild-type (center) or mutant (right) BRCA1.
The assay for unfolding used here has been used with transcriptional activators. It involves targeting BRCA1 or a subset of the protein to multiple (probably several thousand) lacO repeats scattered over 90 Mb of heterochromatin. In 14% of cells expressing BRCA1 linked to the lac repressor there is...
The Rockefeller University Press
2001
The Rockefeller University Press
2001
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