Fruit fly bristles have us tearing out our few remaining hairs. The puzzle is, in forming long bristles, how and why do flies assemble long actin bundles by gluing shorter bundles end-to-end? Fruit fly bristles extend posteriorly in a gentle curve over the fly's back like the hair on a well-groomed individual from the 60's. These bristles, which are cellular extensions of 70 μm in the microchaete and 400 μm in the macrochaete, are supported by a ring of 7–11 cross-linked, membrane-attached actin bundles that run the length of the extension. To generate such an extension and yet to allow curvature of the bristle, the bundles are composed of units or modules, which bend at their junction points (Tilney et al. 1996, Tilney et al. 1998). Fig. 1, a light micrograph of a macrochaete, reveals...
Skip Nav Destination
Article navigation
10 January 2000
Review|
January 10 2000
F-Actin Bundles Are Derivatives of Microvilli: What Does This Tell US about How Bundles Might Form?
David J. DeRosier,
David J. DeRosier
aW.M. Keck Institute of Cellular Visualization, Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, Massachusetts 02454
Search for other works by this author on:
Lewis G. Tilney
Lewis G. Tilney
bDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Search for other works by this author on:
David J. DeRosier
aW.M. Keck Institute of Cellular Visualization, Rosenstiel Basic Medical Sciences Research Center, Department of Biology, Brandeis University, Waltham, Massachusetts 02454
Lewis G. Tilney
bDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Received:
September 07 1999
Revision Requested:
December 03 1999
Accepted:
December 03 1999
Online ISSN: 1540-8140
Print ISSN: 0021-9525
© 2000 The Rockefeller University Press
2000
The Rockefeller University Press
J Cell Biol (2000) 148 (1): 1–6.
Article history
Received:
September 07 1999
Revision Requested:
December 03 1999
Accepted:
December 03 1999
Citation
David J. DeRosier, Lewis G. Tilney; F-Actin Bundles Are Derivatives of Microvilli: What Does This Tell US about How Bundles Might Form?. J Cell Biol 10 January 2000; 148 (1): 1–6. doi: https://doi.org/10.1083/jcb.148.1.1-a
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionSuggested Content
Email alerts
Advertisement
Advertisement