beta-Catenin is involved in the formation of adherens junctions of mammalian epithelia. It interacts with the cell adhesion molecule E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals. We demonstrate here that E-cadherin and APC directly compete for binding to the internal, armadillo-like repeats of beta-catenin; the NH2-terminal domain of beta-catenin mediates the interaction of the alternative E-cadherin and APC complexes to the cytoskeleton by binding to alpha-catenin. Plakoglobin (gamma-catenin), which is structurally related to beta-catenin, mediates identical interactions. We thus show that the APC tumor suppressor gene product forms strikingly similar associations as found in cell junctions and suggest that beta-catenin and plakoglobin are central regulators of cell adhesion, cytoskeletal interaction, and tumor suppression.
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15 December 1994
Article|
December 15 1994
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
J Hülsken,
J Hülsken
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
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W Birchmeier,
W Birchmeier
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
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J Behrens
J Behrens
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
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J Hülsken
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
W Birchmeier
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
J Behrens
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Online ISSN: 1540-8140
Print ISSN: 0021-9525
J Cell Biol (1994) 127 (6): 2061–2069.
Citation
J Hülsken, W Birchmeier, J Behrens; E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.. J Cell Biol 15 December 1994; 127 (6): 2061–2069. doi: https://doi.org/10.1083/jcb.127.6.2061
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