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Stem Cells and Development 2018

Throughout embryonic development and adult life, multicellular organisms depend upon the functioning and tight regulation of self-renewing stem cells that harbor different degrees of potency. These cells are thought to be implicated in the formation of tumors and play important roles in age-related pathologies. Knowledge of the mechanisms that ensure stem cell origin, function and fate, how they respond to the microenvironment, and orchestrate organ development and regeneration is instrumental in understanding healthy development, tissue homeostasis throughout life, and tumor initiation and dissemination.

JCB Editorial Board Member Maria-Elena Torres-Padilla and Senior Scientific Editor Melina Casadio assembled a collection of highly read recent JCB papers investigating morphogenesis, pluripotency and reprogramming, as well as stem cell function during adulthood, aging, and in diseases such as cancer. From 3D culture systems and human stem cell work to model systems, this collection harnesses the power of cell biology to examine the molecular and cellular mechanisms at the center of stem cell behavior and development, in particular in the embryo, germline, nervous system, intestine, bone marrow, and hematopoietic system. The selected studies highlight the complexity of the cell biological, epigenetic, genetic, and signaling mechanisms governing stem cell function and development. We hope you enjoy this special collection and look forward to your feedback on Facebook and Twitter.

Image © 2018 Carroll et al.

Special Collection Image
Article
Cheng-I J. Ma; Yitong Yang; Taeah Kim; Chang Hua Chen; Gordon Polevoy; Miluska Vissa; Jason Burgess; Julie A. Brill
DOI: 10.1083/jcb.201808017
Review
Eric Peterman; Rytis Prekeris
DOI: 10.1083/jcb.201906148
Article
Ling Guo; Ling Guo; Rong Wang; Kuo Zhang; Jifan Yuan; Jiaxin Wang; Xiaoxia Wang; Jianfei Ma; Chuanyue Wu
DOI: 10.1083/jcb.201902022
Spotlight
J. Julian Blow
DOI: 10.1083/jcb.201905181
Review
Kenichiro Taniguchi; Idse Heemskerk; Deborah L. Gumucio
DOI: 10.1083/jcb.201810084
Spotlight
Hilary A. Coller
DOI: 10.1083/jcb.201803037
Article
Thomas D. Carroll; Ian P. Newton; Yu Chen; J. Julian Blow; Inke Näthke
DOI: 10.1083/jcb.201708023
Article
Ling Guo; Ting Cai; Keng Chen; Rong Wang; Jiaxin Wang; Chunhong Cui; Jifan Yuan; Kuo Zhang; Zhongzhen Liu; Yi Deng; Guozhi Xiao; Chuanyue Wu
DOI: 10.1083/jcb.201612177
Article
Tim B. Fessenden; Yvonne Beckham; Mathew Perez-Neut; Guillermina Ramirez-San Juan; Aparajita H. Chourasia; Kay F. Macleod; Patrick W. Oakes; Margaret L. Gardel
DOI: 10.1083/jcb.201703145
In Focus
Ben Short
DOI: 10.1083/jcb.201712044
Article
Joshua Kavaler; Hong Duan; Rajaguru Aradhya; Luis F. de Navas; Brian Joseph; Boris Shklyar; Eric C. Lai
DOI: 10.1083/jcb.201706101
Spotlight
Alejandra I. Romero-Morales; Natalya A. Ortolano; Vivian Gama
DOI: 10.1083/jcb.201710028
Review
Brice E. Keyes; Elaine Fuchs
DOI: 10.1083/jcb.201708099
Article
Tamás Csizmadia; Péter Lőrincz; Krisztina Hegedűs; Szilvia Széplaki; Péter Lőw; Gábor Juhász
DOI: 10.1083/jcb.201702145
Report
Kenichiro Taniguchi; Kenichiro Taniguchi; Yue Shao; Ryan F. Townshend; Chari L. Cortez; Clair E. Harris; Sasha Meshinchi; Sundeep Kalantry; Jianping Fu; K. Sue O’Shea; Deborah L. Gumucio
DOI: 10.1083/jcb.201704085
Report
Annalisa Izzo; Céline Ziegler-Birling; Peter W.S. Hill; Lydia Brondani; Petra Hajkova; Maria-Elena Torres-Padilla; Robert Schneider
DOI: 10.1083/jcb.201611012
In Focus
Ben Short
DOI: 10.1083/jcb.201707076
Report
Christopher L. Koehler; Guy A. Perkins; Mark H. Ellisman; D. Leanne Jones
DOI: 10.1083/jcb.201610036
Article
Chenran Wang; Syn Yeo; Michael A. Haas; Jun-Lin Guan
DOI: 10.1083/jcb.201609093
Article
Gregoire Stik; Simon Crequit; Laurence Petit; Jennifer Durant; Pierre Charbord; Thierry Jaffredo; Charles Durand; Charles Durand
DOI: 10.1083/jcb.201601109
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