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Neurodegenerative Diseases: Emerging Mechanisms and Therapeutic Opportunities

The JCB and JEM editorial teams are delighted to present a selection of recent exciting studies examining molecular, cellular, clinical, and translational aspects of neurodegeneration. The collection features studies of genetic variants and plasma biomarkers associated with Alzheimer’s disease, as well as analyses of the pathophysiology of neurodegeneration and preclinical validation of novel therapeutics.  The collection also includes several articles investigating how changes in neuronal cell biology, such as mitochondrial stress and alterations in cell signaling and trafficking pathways, impact synaptic function and neuronal survival.

This special collection coincides with the JCBJEM symposium on Neurodegeneration “Neurodegenerative Diseases: Emerging Mechanisms and Therapeutic Opportunities” . We welcome your feedback on social media @JCellBiol and @JExpMed.

For more content of interest to neuroscientists, explore the recent JCB Cellular Neurobiology collection and JEM’s collection on Neurodegenerative Diseases: Biology & Therapeutics.

Special Collection Image
Article
Vineet Vinay Kulkarni; Anip Anand; Jessica Brandt Herr; Christina Miranda; Maria Chalokh Vogel; Sandra Maday
DOI: 10.1083/jcb.202002084
Article
Joohyung Kim; Sungdae Kim; Minyeop Nahm; Tsai-Ning Li; Hsin-Chieh Lin; Yeongjin David Kim; Jihye Lee; Chi-Kuang Yao; Seungbok Lee
DOI: 10.1083/jcb.202007112
Article
Kevin D. Rynearson; Moorthi Ponnusamy; Olga Prikhodko; Yuhuan Xie; Can Zhang; Phuong Nguyen; Brenda Hug; Mariko Sawa; Ann Becker; Brian Spencer; Jazmin Florio; Michael Mante; Bahar Salehi; Carlos Arias; Douglas Galasko; Brian P. Head; Graham Johnson; Jiunn H. Lin; Steven K. Duddy; Robert A. Rissman; William C. Mobley; Gopal Thinakaran; Rudolph E. Tanzi; Steven L. Wagner
DOI: 10.1084/jem.20202560
Article
Angeliki Maria Nikolakopoulou; Yaoming Wang; Qingyi Ma; Abhay P. Sagare; Axel Montagne; Mikko T. Huuskonen; Sanket V. Rege; Kassandra Kisler; Zhonghua Dai; Jakob Körbelin; Joachim Herz; Zhen Zhao; Berislav V. Zlokovic
DOI: 10.1084/jem.20202207
Article
Yusuke Fukuda; Maria F. Pazyra-Murphy; Elizabeth S. Silagi; Ozge E. Tasdemir-Yilmaz; Yihang Li; Lillian Rose; Zoe C. Yeoh; Nicholas E. Vangos; Ezekiel A. Geffken; Hyuk-Soo Seo; Guillaume Adelmant; Gregory H. Bird; Loren D. Walensky; Jarrod A. Marto; Sirano Dhe-Paganon; Rosalind A. Segal
DOI: 10.1083/jcb.202005051
Article
Myeong Hoon Han; Min Jee Kwon; Byung Su Ko; Do Young Hyeon; Davin Lee; Hyung-Jun Kim; Daehee Hwang; Sung Bae Lee
DOI: 10.1083/jcb.202004107
Article
Fares Bassil; Emily S. Meymand; Hannah J. Brown; Hong Xu; Timothy O. Cox; Shankar Pattabhiraman; Chantal M. Maghames; Qihui Wu; Bin Zhang; John Q. Trojanowski; Virginia M.-Y. Lee
DOI: 10.1084/jem.20192193
Technical Advances and Resources
Tongfei Liu; Bing Zhu; Yan Liu; Xiaoming Zhang; Jun Yin; Xiaoguang Li; LuLin Jiang; Andrew P. Hodges; Sara Brin Rosenthal; Lisa Zhou; Joel Yancey; Amanda McQuade; Mathew Blurton-Jones; Rudolph E. Tanzi; Timothy Y. Huang; Huaxi Xu
DOI: 10.1084/jem.20200474
Brief Definitive Report
Nicolas R. Barthélemy; Kanta Horie; Chihiro Sato; Randall J. Bateman
DOI: 10.1084/jem.20200861
Report
Rachel J. Hunt; Lucy Granat; Gregory S. McElroy; Ramya Ranganathan; Navdeep S. Chandel; Joseph M. Bateman
DOI: 10.1083/jcb.201904148
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