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Journal Articles

Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres

Wout J. Claassen, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (7): e202213292.
DOI: https://doi.org/10.1085/jgp.202213292
Published: 16 May 2023
View article titled, Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres
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Journal Articles

Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit

Miaomiao He, Lonnie P. Wollmuth
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202313391.
DOI: https://doi.org/10.1085/jgp.202313391
Published: 03 May 2023
View article titled, Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit
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Journal Articles

How can AI accelerate advances in physiology?

Andrew D. McCulloch
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (6): e202313388.
DOI: https://doi.org/10.1085/jgp.202313388
Published: 27 April 2023
View article titled, How can AI accelerate advances in physiology?
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Journal Articles

Heteromeric wild-type/mutant potassium channel subunit composition as a major determinant of channelopathy phenotype in heterozygous patients

Tinatin I. Brelidze
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202313333.
DOI: https://doi.org/10.1085/jgp.202313333
Published: 14 April 2023
View article titled, Heteromeric wild-type/mutant potassium channel subunit composition as a major determinant of channelopathy phenotype in heterozygous patients
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Journal Articles

Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation

László Csanády
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202313336.
DOI: https://doi.org/10.1085/jgp.202313336
Published: 05 April 2023
View article titled, Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation
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Journal Articles

Tweaking the catalytic efficiency of the CFTR ion channel

Nael A. McCarty
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (5): e202313343.
DOI: https://doi.org/10.1085/jgp.202313343
Published: 04 April 2023
View article titled, Tweaking the catalytic efficiency of the CFTR ion channel
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Journal Articles

Sensing its own permeant ion: KCNQ1 channel inhibition by external K+

Rene Barro-Soria
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (5): e202313337.
DOI: https://doi.org/10.1085/jgp.202313337
Published: 24 March 2023
View article titled, Sensing its own permeant ion: KCNQ1 channel inhibition by external K<sup>+</sup>
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Journal Articles

Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?

David Y. Barefield
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2023) 155 (4): e202313351.
DOI: https://doi.org/10.1085/jgp.202313351
Published: 22 March 2023
View article titled, Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?
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Journal Articles

A loosely coordinated interaction site for arachidonic acid on ASICs

Robert C. Klipp, John R. Bankston
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (3): e202213307.
DOI: https://doi.org/10.1085/jgp.202213307
Published: 01 February 2023
View article titled, A loosely coordinated interaction site for arachidonic acid on ASICs
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Journal Articles

Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD

Arthur J. Cheng, Ferdinand von Walden, Johanna T. Lanner
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2023) 155 (2): e202213224.
DOI: https://doi.org/10.1085/jgp.202213224
Published: 03 January 2023
View article titled, Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD
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Journal Articles

Calcium activation through thick and thin?

Michael J. Previs
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2022) 155 (1): e202213265.
DOI: https://doi.org/10.1085/jgp.202213265
Published: 16 December 2022
View article titled, Calcium activation through thick and thin?
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Journal Articles

Seeing spermine blocking of K+ ion movement through inward rectifier Kir2.2 channels

Sun-Joo Lee, Colin G. Nichols
Journal: Journal of General Physiology
J Gen Physiol (2022) 155 (2): e202213144.
DOI: https://doi.org/10.1085/jgp.202213144
Published: 16 December 2022
View article titled, Seeing spermine blocking of K<sup>+</sup> ion movement through inward rectifier Kir2.2 channels
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Journal Articles

Variants of the myosin interacting-heads motif

Raúl Padrón, Debabrata Dutta, Roger Craig
Journal: Journal of General Physiology
Series: Myofilament Function 2022
J Gen Physiol (2022) 155 (1): e202213249.
DOI: https://doi.org/10.1085/jgp.202213249
Published: 08 November 2022
View article titled, Variants of the myosin interacting-heads motif
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Journal Articles

Interrogating the gating motions of the NaK channel

Brad S. Rothberg
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (12): e202213257.
DOI: https://doi.org/10.1085/jgp.202213257
Published: 03 November 2022
View article titled, Interrogating the gating motions of the NaK channel
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Journal Articles

The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating

Laurent Ferron, Gerald W. Zamponi
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (11): e202213272.
DOI: https://doi.org/10.1085/jgp.202213272
Published: 20 October 2022
View article titled, The road to the brain in Timothy syndrome is paved with enhanced Ca<sub>V</sub>1.2 activation gating
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Journal Articles

The spatial distribution of glycogen and glycogen consumption in muscle cells

David G. Allen
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2022) 154 (9): e202213238.
DOI: https://doi.org/10.1085/jgp.202213238
Published: 17 August 2022
View article titled, The spatial distribution of glycogen and glycogen consumption in muscle cells
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Journal Articles

From α1s splicing to γ1 function: A new twist in subunit modulation of the skeletal muscle L-type Ca2+ channel

Werner Melzer
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2022) 154 (9): e202213182.
DOI: https://doi.org/10.1085/jgp.202213182
Published: 08 June 2022
View article titled, From α<sub>1</sub>s splicing to γ<sub>1</sub> function: A new twist in subunit modulation of the skeletal muscle L-type Ca<sup>2+</sup> channel
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Journal Articles

The surprising difficulty of “simple” equilibrium binding measurements on ligand-gated ion channels

Thomas R. Middendorf, Marcel P. Goldschen-Ohm
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (7): e202213177.
DOI: https://doi.org/10.1085/jgp.202213177
Published: 02 June 2022
View article titled, The surprising difficulty of “simple” equilibrium binding measurements on ligand-gated ion channels
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Journal Articles

Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca2+ in cardiomyocytes?

Naohiro Yamaguchi
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2022) 154 (9): e202213078.
DOI: https://doi.org/10.1085/jgp.202213078
Published: 25 May 2022
View article titled, Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca<sup>2+</sup> in cardiomyocytes?
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Journal Articles

ASIC3, a proton-gated ion channel with preference for polyunsaturated lipids with specific headgroup and tail properties

Sara I. Liin
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (7): e202213171.
DOI: https://doi.org/10.1085/jgp.202213171
Published: 18 May 2022
View article titled, ASIC3, a proton-gated ion channel with preference for polyunsaturated lipids with specific headgroup and tail properties
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