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JGP Reviews: Ion Channel Structure and Function

We are pleased to present a collection of Reviews on the structure and function of ion channels, which have been curated from recent issues of JGP for their relevance to The Austin Conference on Ion Channel Dynamics and Mechanisms.

Ion channels are proteins that are present in the membranes of virtually all living cells. They transport charged ions from one side of a membrane to the other, thus their activity can be observed with electrical recording techniques. The first recordings of single ion channels openings were published in JGP fifty years ago. Thirty years later, the first ion channel structure was revealed, and hundreds more – of numerous different channels in multiple conformations – have been published since then. Experiments to determine the functional correlate of each of these structural conformations are now more important than ever so that a detailed understanding ion channel mechanisms can be achieved.

Reviews in this collection discuss ground-breaking work at the structure–function interface for a range of different channels, including those activated by voltage, ligands, ions and cell swelling. We hope you enjoy reading the articles, which are all freely available for a limited period.

Image ©: 2019 Twomey et al.

Special Collection Image
Review
Edward C. Twomey; Maria V. Yelshanskaya; Alexander I. Sobolevsky
DOI: 10.1085/jgp.201812264
Review
Kevin Strange; Toshiki Yamada; Jerod S. Denton
DOI: 10.1085/jgp.201812138
Review
Kasper B. Hansen; Feng Yi; Riley E. Perszyk; Hiro Furukawa; Lonnie P. Wollmuth; Alasdair J. Gibb; Stephen F. Traynelis
DOI: 10.1085/jgp.201812032
Review
Maria E. Falzone; Mattia Malvezzi; Byoung-Cheol Lee; Alessio Accardi
DOI: 10.1085/jgp.201711957
Review
Michael C. Puljung
DOI: 10.1085/jgp.201711978
Review
Tzyh-Chang Hwang; Jiunn-Tyng Yeh; Jingyao Zhang; Ying-Chun Yu; Han-I Yeh; Samantha Destefano
DOI: 10.1085/jgp.201711946
Review
Zachary M. James; William N. Zagotta
DOI: 10.1085/jgp.201711898
Review
Gerhard Meissner
DOI: 10.1085/jgp.201711878
Review
Yu Zhou; Huanghe Yang; Jianmin Cui; Christopher J. Lingle
DOI: 10.1085/jgp.201711845
Review
Teresa Giraldez; Brad S. Rothberg
DOI: 10.1085/jgp.201611726
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