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Insights from Miwa Sasai (left) and Masahiro Yamamoto (right).
Published: 22 January 2020
Insights from Miwa Sasai (left) and Masahiro Yamamoto (right). More
Images
T    . gondii      injects ROP16 to polarize macrophage toward M2 macrophag...
Published: 22 January 2020
T . gondii injects ROP16 to polarize macrophage toward M2 macrophage without infection. After attachment to the host cell, T. gondii injects rhoptry contents with or without invasion. ROP16 is also injected to activate host transcription factors STAT3 and STAT6, resulting in expression of... More
Images
Plaque-associated myeloid cells are resident, yolk sac–derived microglia.  ...
Published: 22 January 2020
Figure 1. Plaque-associated myeloid cells are resident, yolk sac–derived microglia. (A) Schematic for tamoxifen exposure to drive expression of tdTomato in Cx3cr1 CreERT2 ; 5xFAD; ROSA26 tdTomato (top, purple) or Ccr2 CreERT2 ; 5xFAD; ROSA26 tdTomato (bottom, yellow) mice. Tamoxifen treat... More
Images
Kinetics of labeled peripheral monocytes using  Ccr2-CreERT2 .  The fractio...
Published: 22 January 2020
Figure S1. Kinetics of labeled peripheral monocytes using Ccr2-CreERT2 . The fraction of monocytes (MOs; CD11b + CD115 + ), neutrophils (NPs; CD11b + Ly6G + ), and dendritic cells (DCs; CD11b + CD11c + MHCII + ) expressing tdTomato immediately after 5 d of tamoxifen-containing chow, or followin... More
Images
Labeling of peripheral monocyte populations following tamoxifen exposure.  ...
Published: 22 January 2020
Figure 2. Labeling of peripheral monocyte populations following tamoxifen exposure. (A) Representative flow sorting scheme for tdTomato expression in Ly6C hi and Ly6C lo monocytes from the spleen. FSC, forward scatter; SSC, side scatter. (B and C) Fraction of Ly6C hi and Ly6C lo monocytes... More
Images
An in vitro priming approach to generate functional pathogen-specific Th ce...
Published: 22 January 2020
Figure S1. An in vitro priming approach to generate functional pathogen-specific Th cells. (A) Top: Purity of isolated naive CD4 T cells (CD4 + MHCII − CD62L + CD44 − ) from two independent experiments. Bottom: Purity of CD11c + DCs before or after isolation. (B) Overlay histograms of CFSE d... More
Images
Validation of an in vitro–priming approach to generate functional pathogen-...
Published: 22 January 2020
Figure 1. Validation of an in vitro–priming approach to generate functional pathogen-specific Th cells. (A) Schematic overview of the priming system and workflow. (B) Top row: Representative CFSE dilution graph and cytokine (IFNγ and IL-17A) staining from CFSE + and CFSE − populations. Bott... More
Images
Comparative transcriptional analysis reveals caspase-1 as a T cell–intrinsi...
Published: 22 January 2020
Figure S2. Comparative transcriptional analysis reveals caspase-1 as a T cell–intrinsic regulator of Th17 differentiation. (A) tdT + percentage of unstimulated (Un), Lm-primed, Cr-primed, or Th17-polarized 17A-fm CD4 T cells. Un, n = 4; Lm and Cr, n = 5; Th17, n = 2. (B) Heatmap of Th1... More
Images
Comparative transcriptional analysis reveals major divergence in programmin...
Published: 22 January 2020
Figure 2. Comparative transcriptional analysis reveals major divergence in programming between ppTh17 and cdTh17 cells . (A) Experimental design for transcriptional profiling of CFSE + (naive), ppTh17 (Cr-specific, day 12), cdTh17 (day 5), or ex vivo tdT + cells (10 dpi/peak of infection with... More
Images
Caspase-1 promotes the differentiation of Th17 lineage independent of its e...
Published: 22 January 2020
Figure 3. Caspase-1 promotes the differentiation of Th17 lineage independent of its enzymatic activity or inflammasome activation. (A) Differentially expressed transcripts between ppTh17 and cdTh17 cells. Each dot represents the average of three independent experiments. Blue dots indicate diffe... More
Images
T cell–intrinsic caspase-1 is required for host protection and Th17-mediate...
Published: 22 January 2020
Figure S3. T cell–intrinsic caspase-1 is required for host protection and Th17-mediated autoinflammatory disease. (A) Naive CD4 T cells from WT or Casp1Δ10 (Δ10) mice were isolated and polarized to cdTh17 cells. Representative flow cytometry plot (left) and quantifications of IL-17A + percenta... More
Images
T cell–intrinsic caspase-1 is required for host protection against Cr .   (...
Published: 22 January 2020
Figure 4. T cell–intrinsic caspase-1 is required for host protection against Cr . (A) Schematic of the experiment. (B) Representative intracellular cytokine staining of IFNγ, IL-22, and IL-17A in CD4 + CD90 + CD44 + T cells in the mLNs at 10 dpi of Cr. (C) Quantification of IL-17A + IL-22... More
Images
T cell–intrinsic caspase-1 is required for Th17-mediated colitis.  (A)  Wei...
Published: 22 January 2020
Figure 5. T cell–intrinsic caspase-1 is required for Th17-mediated colitis. (A) Weight change of Rag1 − / − mice that received WT, Casp1Δ10, or Il1b − / − naive CD4 T cells (CD45RB hi ) at indicated time points ( n = 6–10 mice for each group). NT, nontransferred (i.p. PBS). (B) ... More
Journal Articles
The Journal of Experimental Medicine (2020) 217 (4): e20191374.
Published: 22 January 2020
Journal Articles
The Journal of Experimental Medicine (2020) 217 (4): e20190476.
Published: 22 January 2020
Includes: Supplementary data
Journal Articles
The Journal of Experimental Medicine (2020) 217 (3): e20192145.
Published: 22 January 2020
Journal Articles
The Journal of Experimental Medicine (2020) 217 (2): e20200046.
Published: 21 January 2020
Journal Articles
The Journal of Experimental Medicine (2020) 217 (3): e20191226.
Published: 20 January 2020
Includes: Supplementary data
Images
The dissipation of electrons (Δ Y ) in metabolic transformations.  Δ Y  is ...
Published: 20 January 2020
Figure 1. The dissipation of electrons (Δ Y ) in metabolic transformations. Δ Y is calculated by Eq. 2 based on the Y values in Table 1 and Table S1 . (A) Δ Y in ATP generation. The inset is mitochondrial ATP generation. (B) Δ Y in the biosynthesis of nucleosides. Ribose can be gen... More
Images
Intracellular metabolic overview.  The metabolic pathways were organized ba...
Published: 20 January 2020
Figure S1. Intracellular metabolic overview. The metabolic pathways were organized based on Berg et al. (2011) . The red arrows show the irreversible direction of the reactions. The synthesis of each nucleotide is summarized in Fig. S2 and Table S3 . 1,3-BPG, 1,3-bisphosphoglycerate; 2-PG, 2... More